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How can I know if the does amounts of key ingredients in my supplement are enough to create the health benefits shown in clinical studies ?Ahh - that’s the key question for supplement users but it’s very difficult to answer. Vitamins and minerals are not a problem but for other ingredients the only real way to know is through a thorough examination of scientific evidence - a lengthy and tedious process. On-top of that most people don’t know how to evaluate the quality of clinical studies. For today I want to introduce you to 4 standards which the most effective supplements meet. You can use any nutritional supplement formulas to check on these standards, providing they contain the ingredients involved. They show the clinically proven beneficial range for dose amounts of some important ingredients. These ranges have been scientifically validated by well accepted research or based on expert assumptions on clinical studies. They come from the Pharmanex Company who uses them (as at Jan 2006) as part of a range of standards they’ve created to conduct challenges against their own product ‘Lifepak’ – one of the supplements I’ve evaluated and reviewed in nutritional-supplement-truths.com. I have conducted my own research to confirm the validity of the supporting research used by Pharmanex to create these 4 standards. Any supplement marketed as a high quality, comprehensive product aimed at promoting overall good health by:
must meet these 4 standards! That’s not to say that these standards are any kind of official criteria for determining quality supplements. They were obviously created to show Lifepak in the best light. Other studies could no doubt be used to adjust these criteria but none-the-less they are backed by good science and serve as a credible guideline for focusing in on the most efficacious supplements. The ingredients involved are: 1. B Vitamins used in homocysteine metabolismHomocysteine is an amino acid found in the blood and high homocysteine levels are strongly linked to heart disease – the most common cause of death in the US. Even mildly elevated levels increase your chances of death from any cause - not just heart disease.The key B Vitamins we need to consider are:
2. FlavonoidsFlavonoids are a class of phytonutrients which have powerful medicinal properties. They show anti-allergic, anti-inflammatory, anti-microbial and anti-cancer activity."The beneficial effects of fruit, vegetables, and tea or even red wine have been attributed to flavonoid compounds rather than to known nutrients and vitamins." (2) If you don’t know whether your supplement has any flavonoids, check this list of the most important ones:
3. Carotenoids.Carotenoids are another important category of phytonutrients with many well documented health promoting properties (e.g. anti-cancer). The best sources are fruits and vegetables which is why we should all aim to eat a lot more of these disease preventing foods!!Common carotenoids are beta-carotene, alpha-carotene, lutein, zeaxanthin, lycopene, and cryptoxanthin (3) Quality supplements supply beneficial amounts of these potent phytonutrients. * Pharmanex does not include Zeaxanthin in this standard but I have included it because it is a potent carotenoid beneficial for vision – it is an expensive ingredient but should be there. 4. Trace MineralsMinerals are critical components of many body functions that support good health but they are difficult to absorb. Bioavailability and intestinal absorption is increased when minerals are included in the organic salt form or as amino acid chelates.Research shows that this benefit is significant only for zinc, iron, copper and to a lesser degree chromium. Quality nutritional supplement formulas will contain minerals in these more expensive, bioavailable forms. Use these Standards To Compare The Best Nutritional Supplement FormulasTo view the standards please download this PDF file here
There are thousands of "high potency" multi vitamin and mineral supplements in the market – beware. When it comes to vitamins – more is not better!Americans in particular have been bombarded into a general belief that they need high levels of vitamins and minerals in supplements – up to 100% of the RDA’s and often more. Keep in mind that vitamins are the cheapest components for supplement manufacturers to include - very cheap!Remember - good old vitamin C (Ascorbic acid) costs approx. $15 per kilo whereas some phytonutrients cost more than $1000 per kilo!! Certain groups of people may need high to very high doses of some vitamins/minerals for specific reasons (e.g. sickness, pregnancy) but they are the exception. If you are not in this category you should not exceed the figures listed in the table below. These limits are from the No-Observed Adverse Effect Levels (NOAEL) list created by the Council for Responsible Nutrition (CRN). This serves as a credible guideline for safe upper limits of vitamins and minerals. CRN is a Washington-based trade association representing ingredient suppliers and manufacturers in the dietary supplement industry. Safe Upper LimitsView the safe upper limits for vitamins and minerals by downloading this PDF file hereAlthough nutritional supplement formulas are complex things you can still use them as part of a range of criteria to break a supplement apart in order to thoroughly evaluate it from different perspectives. Examining the forms, dosage amounts and total number of ingredients in a multi nutrient supplement, gives you a good indication of just how much quality, effectiveness, safety and value for money has been built in. By combining this, along with the answers you get from using the other 5 evaluation criteria explained at nutritional-supplement-truths.com; you’ll get to know without any doubt just how good a supplement really is. You'll have no trouble finding the best multi nutrient supplement on the market today. (Hint: It’s one of the industry leading super supplements reviewed in this site. Study the evaluation charts and product reviews throughout the site - or perhaps you may like to redo the evaluations yourself without looking at my work). Alternatively if you're pressed for time and want to get straight to the name of the best vitamin supplement, you can take this shortcut route to my best vitamin supplements - best product page to find the answer. Ok - that’s it for nutritional supplement formulas. Let’s move on to the next really important evaluation criteria – Ingredient quality in nutritional supplements Nutritional Supplement Formulas - Sources: (1) Droge, W. and Breitkreutz, R., "Glutathione and immune function," Proc. Nutr. Soc., 59, 595-600 (2000). (2) Wikipedia website. http://en.wikipedia.org/wiki/Flavonoid (3) Office of Dietary Supplements website. http://www.ods.od.nih.gov/factsheets/vitamina.asp
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